ClearNote Health Publications Based on more than 50,000 assays with samples collected across over 150 sites, ClearNote Health has produced multiple peer-reviewed papers including detection data from several cancer types, including pancreatic and ovarian. November 2025 5-hydroxymethylcytosine analysis reveals stable epigenomic changes in tumor tissue that enable cancer detection in cell-free DNA Communications Biology September 2024 Analytical Validation of an Early Detection Pancreatic Cancer Test Using 5-Hydroxymethylation Signatures The Journal of Molecular Diagnostics November 2023 Plasma cell-free DNA hydroxymethylation profiling reveals anti-PD-1 treatment response and resistance biology in non- small cell lung cancer Journal for ImmunoTherapy of Cancer March 2023 Epigenomic Blood-Based Early Detection of Pancreatic Cancer Employing Cell-Free DNA Clinical Gastroenterology and Hepatology October 2022 The 5-Hydroxymethylcytosine Landscape of Prostate Cancer Cancer Research July 2022 The Cell Type-Specific 5hmC Landscape and Dynamics of Healthy Human Hematopoiesis and TET2-Mutant Preleukemia Blood Cancer Discovery December 2020 A human tissue map of 5-hydroxymethylcytosines exhibits tissue specificity through gene and enhancer modulation Nature Communications October 2020 Detection of early stage pancreatic cancer using 5-hydroxymethylcytosine signatures in circulating cell free DNA Nature Communications 12>> Epigenomics-based Tests for Early Cancer Detection Learn About Our Tests
