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A tumor-naïve method for estimating tumor fraction using 5-hydroxymethylation cytosine in cell–free DNA

ClearNote Health
February 2, 2026

5hmC-seq of mCRPC cfDNA identifies loss of AR signaling in NEPC and DNPC

ClearNote Health
February 2, 2026

Cell-free DNA 5-hydroxymethylcytosine Profiling for the Assessment of Colorectal Cancer Biology and Treatment Response in Blood.

ClearNote Health
February 2, 2026

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Important information: 
The Virtuoso platform is for research use only. Not for use in diagnostic procedures.

The Avantect Pancreatic and Ovarian Cancer Tests are early detection tests. The tests do not establish a diagnosis of pancreatic or ovarian cancer, and results should be considered in the context of other clinical criteria. Definitive diagnosis of pancreatic or ovarian cancer usually requires a series of imaging scans, blood tests, and a biopsy. Not all pancreatic or ovarian cancers will be detected. Some patients with pancreatic or ovarian cancer may have a “Pancreatic/Ovarian Cancer Signal not detected” result. Some patients without pancreatic or ovarian cancer may have a “Pancreatic/Ovarian Cancer Signal detected” result. False-negative and false-positive results are possible. A “Signal not detected” result does not guarantee that no pancreatic or ovarian cancer is present. In some cases, no result is obtained. While this is very uncommon, it may be caused by shipping delays or when there is not enough cell-free DNA for the test in the patient’s blood. If this happens, we generally ask for a repeat blood sample for testing at no extra cost.

The tests were developed in the ClearNote Health CLIA-certified (CLIA# 05D2249973) and CAP-accredited (CAP# 9219174) laboratory and have not been cleared or approved by the US Food and Drug Administration (FDA).

Cancer statistics quoted on this website are taken from the CDC and SEER websites, 2025 data.

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